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pentobarbital will lessen the extent or effect of cyclosporine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.Monitor Closely (one)pentobarbital will lower the level or outcome of tofacitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Loss of, or lessened reaction to tofacitin